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Building upon previous studies, the scientists studied the synthesis and breakdown of fats and proteins over 24 hours – an approach that might also be interesting for athletes.In collaboration with Italian and Austrian colleagues (from the Venetian Institute of Molecular Medicine and the Universities of Padua, Graz, and Trieste) the researchers identified certain processes that are switched on at night by the regulators of the internal clock: “They include, for example, fat storage, glucose metabolism and insulin sensitivity,” explains Henriette Uhlenhaut.All you have to do is answer a couple of simple questions and you’re ready to go.
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Further Information Background: Specifically, the authors compared the genome-wide binding of the two transcription factors BMAL1 and REV-ERBα. (2018): Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock.
The authors Michaël Hubert and Katrin Fischer are participants in the Helmholtz Graduate School Environmental Health program, or HELENA for short. PLOS Biology, DOI: 10.1371/2005886 As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases.
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